RESEARCH PROJECT
1/ Study the interplay between platelets and immune cells in systemic lupus erythematosus.
To achieve this, we work on patient samples and mouse models to dissect the proinflammatory effect of platelets on various immune cells such as neutrophils and T regulatory cells.
We are using new technologies to achieve this aim using spectral cytometry (Aurora), single cell RNAseq and spatial transcriptomioc.
The ultimate aim is to repurpose drugs which target platelet-immune cell interaction (ie, anti-P-selectin antibodies) as systemic lupus treatment.
2/ Evaluate the efficacy of novel immunotherapies in autoimmune diseases :
Chimeric antigen receptor (CAR) T cells represent an opportunity to induce long term remission in patients with severe autoimmune diseases such as systemic lupus. However, several challenges hinders the use of CAR-T cells, such as its costs, its potential safety issues and the heaviness of the procedure itself. We aim to compare CAR-T cells strategies with other innovative immunotherapies in various mouse models of autoimmune diseases. The tested immunotherapies include T-cell engagers, NK-cell engagers, NK CARs, CAR Tregs …
