Research Project
The broad, long term goal of our group – gathering clinician-scientists (rheumatologists, nephrologists and pediatric hematologists), basic/translational scientists (immunologists, geneticists, virologists), engineers (bioinformaticians, molecular biologists), post-docs, graduate students and technicians – is to study the diversity of the immune system and the immune response. Using modern techniques of molecular and cell biology, highly curated patient cohorts and relevant animal models we aim in particular at tackling important biomedical questions with regards to immunogenetics/histocompatibility and rheumatology.
In the field of immunogenetics/histocompatibility, we are interested in high-throughput genomics of immune/inflammatory diseases and transplantation. This work is performed in the framework of the Laboratory of Excellence (LabEx) TRANSPLANTEX headed by Seiamak Bahram and gathering more than 200 staff across the country. In the field of autoimmunity, we are applying multi-omics strategies to decipher complex and multifactorial diseases such as systemic sclerosis or primary Sjögren’s disease. Finally, whenever possible results are transposed to concrete medical applications, mostly in the field of diagnostics.
The team is also a leading member of two further collaborative initiatives including:
-The Hospital-University Federation (FHU) OMICARE (omics+care) focused on multi-omics based stratification of autoimmune and autoinflammatory disease patients
-The PACIFIC Institute dedicated to personalized medicine of immune-mediated inflammatory diseases: http://www.ihu-pacific.eu/
Collaborations
Our group has established multiple collaborations with national and international scientists. Here are a few examples of main collaborators: Dr. Bertrand Isidor (Hospital of Nantes, France), Prof. Gérard Socié (Hospital St. Louis, Paris, France), Prof. Hidetoshi INOKO (Tokai University, Japan), Prof. Masao OTA (Shinshu University, Matsumoto, Nagano, Japan), Prof. Claudia Lengerke (Universityof Basel, Basel, Switzerland), Prof. Akiko Shimamura (Boston Children’s Hospital, Boston, USA), Prof. Caner Süsal (Institute of Immunology, Heidelberg, Germany), Prof. Robert Zeiser (University Hospital Freiburg, Germany), Prof. Fai Ng (Newcastle University, UK),…
Funding
- Cancéropole Grand-Est,
- Feder dont Interreg V
- Eurométropole de Strasbourg
- Ministère de l’enseignement supérieur et de la recherche
- Investissements d’avenir
- Conseil général du Bas-Rhin
- Région Grand Est
- Inserm
- Université de Strasbourg
- MSD Avenir
- IUF
- ANR
Publications
Molitor A, Prud’homme T, Miao Z, Conrad S, Bloch-Zupan A, Pichot A, Hanauer A, Isidor B, Bahram S, Carapito R.
J Hum Genet. 2019 Jul;64(7):689-694. doi: 10.1038/s10038-019-0615-3. Epub 2019 May 8.
HLA*LA-HLA typing from linearly projected graph alignments.
Dilthey AT, Mentzer AJ, Carapito R, Cutland C, Cereb N, Madhi SA, Rhie A, Koren S, Bahram S, McVean G, Phillippy AM.
Bioinformatics. 2019 Nov 1;35(21):4394-4396. doi: 10.1093/bioinformatics/btz235.
ZMIZ1 Variants Cause a Syndromic Neurodevelopmental Disorder.
Carapito R, Ivanova EL, Morlon A, Meng L, Molitor A, Erdmann E, Kieffer B, Pichot A, Naegely L, Kolmer A, Paul N, Hanauer A, Tran Mau-Them F, Jean-Marçais N, Hiatt SM, Cooper GM, Tvrdik T, Muir AM, Dimartino C, Chopra M, Amiel J, Gordon CT, Dutreux F, Garde A, Thauvin-Robinet C, Wang X, Leduc MS, Phillips M, Crawford HP, Kukolich MK, Hunt D, Harrison V, Kharbanda M; Deciphering Developmental Disorders Study; University of Washington Center for Mendelian Genomics, Smigiel R, Gold N, Hung CY, Viskochil DH, Dugan SL, Bayrak-Toydemir P, Joly-Helas G, Guerrot AM, Schluth-Bolard C, Rio M, Wentzensen IM, McWalter K, Schnur RE, Lewis AM, Lalani SR, Mensah-Bonsu N, Céraline J, Sun Z, Ploski R, Bacino CA, Mefford HC, Faivre L, Bodamer O, Chelly J, Isidor B, Bahram S.
Am J Hum Genet. 2019 Feb 7;104(2):319-330. doi: 10.1016/j.ajhg.2018.12.007. Epub 2019 Jan 10.
Domingo-Calap P, Schubert B, Joly M, Solis M, Untrau M, Carapito R, Georgel P, Caillard S, Fafi-Kremer S, Paul N, Kohlbacher O, González-Candelas F, Bahram S.
PLoS Pathog. 2018 Oct 18;14(10):e1007368. doi: 10.1371/journal.ppat.1007368. eCollection 2018 Oct.
Multi-OMICS analyses unveil STAT1 as a potential modifier gene in mevalonate kinase deficiency.
Carapito R, Carapito C, Morlon A, Paul N, Vaca Jacome AS, Alsaleh G, Rolli V, Tahar O, Aouadi I, Rompais M, Delalande F, Pichot A, Georgel P, Messer L, Sibilia J, Cianferani S, Van Dorsselaer A, Bahram S.
Ann Rheum Dis. 2018 Nov;77(11):1675-1687. doi: 10.1136/annrheumdis-2018-213524. Epub 2018 Jul 20.
Neutralizing Antibody-Mediated Response and Risk of BK Virus-Associated Nephropathy. Solis M, Velay A, Porcher R, Domingo-Calap P, Soulier E, Joly M, Meddeb M, Kack-Kack W, Moulin B, Bahram S, Stoll-Keller F, Barth H, Caillard S, Fafi-Kremer S. J Am Soc Nephrol, 2018
Natural Killer Group 2, Member D/NKG2D Ligands in Hematopoietic Cell Transplantation. Carapito R, Aouadi I, Ilias W, Bahram S. Front Immunol, 2017
A new MHC-linked susceptibility locus for primary Sjögren’s syndrome: MICA. Carapito R, Gottenberg JE, Kotova I, Untrau M, Michel S, Naegely L, Aouadi I, Kwemou M, Paul N, Pichot A, Locke J, Bowman SJ, Griffiths B, Sivils KL, Sibilia J, Inoko H, Micelli-Richard C, Nocturne G, Ota M, Ng WF, Mariette X, Bahram S. Hum Mol Genet, 2017
Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond-like features. Carapito R, Konantz M, Paillard C, Miao Z, Pichot A, Leduc MS, Yang Y, Bergstrom KL, Mahoney DH, Shardy DL, Alsaleh G, Naegely L, Kolmer A, Paul N, Hanauer A, Rolli V, Muller JS, Alghisi E, Sauteur L, Macquin C, Morlon A, Sancho CS, Amati-Bonneau P, Procaccio V, Mosca-Boidron AL, Marle N, Osmani N, Lefebvre O, Goetz JG, Unal S, Akarsu NA, Radosavljevic M, Chenard MP, Rialland F, Grain A, Bene MC, Eveillard M, Vincent M, Guy J, Faivre L, Thauvin-Robinet C, Thevenon J, Myers K, Fleming MD, Shimamura A, Bottollier-Lemallaz E, Westhof E, Lengerke C, Isidor B, Bahram S. J Clin Invest, 2017
The TRANSPLANTEX initiative. Bahram S, Carapito R, Gourraud PA, Charron D. Hum Immunol, 2016
Protein-altering MYH3 variants are associated with a spectrum of phenotypes extending to spondylocarpotarsal synostosis syndrome. Carapito R, Goldenberg A, Paul N, Pichot A, David A, Hamel A, Dumant-Forest C, Leroux J, Ory B, Isidor B, Bahram S. Eur J Hum Genet, 2016
Matching for the nonconventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD. Carapito R, Jung N, Kwemou M, Untrau M, Michel S, Pichot A, Giacometti G, Macquin C, Ilias W, Morlon A, Kotova I, Apostolova P, Schmitt-Graeff A, Cesbron A, Gagne K, Oudshoorn M, van der Holt B, Labalette M, Spierings E, Picard C, Loiseau P, Tamouza R, Toubert A, Parissiadis A, Dubois V, Lafarge X, Maumy-Bertrand M, Bertrand F, Vago L, Ciceri F, Paillard C, Querol S, Sierra J, Fleischhauer K, Nagler A, Labopin M, Inoko H, von dem Borne PA, Kuball J, Ota M, Katsuyama Y, Michallet M, Lioure B, Peffault de Latour R, Blaise D, Cornelissen JJ, Yakoub-Agha I, Claas F, Moreau P, Milpied N, Charron D, Mohty M, Zeiser R, Socie G, Bahram S. Blood, 2016
Next-Generation Sequencing of the HLA locus: Methods and impacts on HLA typing, population genetics and disease association studies. Carapito R, Radosavljevic M, Bahram S. Hum Immunol, 2016
Back to the future: bacteriophages as promising therapeutic tools. Domingo-Calap P, Georgel P, Bahram S. HLA, 2016
Circulating Human Eosinophils Share a Similar Transcriptional Profile in Asthma and Other Hypereosinophilic Disorders. Barnig C, Alsaleh G, Jung N, Dembele D, Paul N, Poirot A, Uring-Lambert B, Georgel P, de Blay F, Bahram S. PLoS One, 2015